Description
Product Characteristics: For quantitative detection of INTS3 in serum, plasma, tissue homogenates.
Target Information: INTS3 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A\, MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1\, MIM 180680) and U2 (RNU2\, MIM 180690) (Baillat et al., 2005 [PubMed 16239144]). INTS3 is also a subunit of single-stranded DNA (ssDNA)-binding complexes involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]